染色体易位携带者的胚胎植入前遗传学诊断研究进展.pdfVIP

76 2002 2 19 1 Chin J Med Genet February, 2002, Vol. 19, No. 1 谭跃球　卢光王秀　李麓芸 , , ; ; Advances in preimplantation genetic diagnosis f or chromosomal translocation carrier* TA N Y ueq iu , L U Guangx iu , LI L uy un . ( H uman R ep r oductiv e E ng ineering L abor atory , X iangy a M edica Co eg e, Centr a -South Univ er sity , Changsha , H unan, 410078 P .R . China . E -mai : gx director @ sina .com) . A bstract Chromosomal translocation is a kind of com mon chrom osomal abnormality he carriers w ith chromosomal translocation could have more chance of normal pregnancy with t he help of fluorescence in situ hybridization FISH( ) . his is a review aimed at analyzing the meiosis types of the translocation chromosome. he strategy of preimplantat ion genetic diagnosis for t he carriers with chromosomal translocation is also discussed. Key words chrom osomal translocation; fluorescence in situ hybridization; preimplantation genetic diagnosis * Supported by the National Natur al Science Foundation of China ( Project for young scientists fund, Proj. No. , Hunan Natural Science Foundation Proj No( . . 1013-8) , and Hunan Foundation for Medicine and Health ( Proj. No. 0002) , PGD , PGD [ 9] , , PGD , [ 1] , , 1 , , , , ,PGD , 6 , 1 (preimplantation genetic diagnosis, PGD) , 1, 4 [ 10] , PGD ( in vitro