制何首乌和白蒺藜对小鼠毒性作用的实验研究.pdfVIP

制何首乌和白蒺藜对小鼠毒性作用的实验研究△ 夏蕾’，王丽霞，牟稷征(中国中医科学院广安门医院药剂科，北京市100053) 中图分类号 R965 文献标识码 B 文章编号 1672—2124(2010)01—0034一02 摘要 目的：研究制何首乌和白蒺藜对小鼠的毒性作用。方法：通过测定制何首鸟和白蒺藜的半数致死量及最大耐受量来评 价两种药物的急性毒性。将实验小鼠分为空白组、制何首乌组、白蒺藜组及制何首鸟伍用白蒺藜组，按临床常用剂量灌胃2周后 观察两药单用及伍用后对小鼠肝脏的毒性作用。结果：小鼠对制何首乌和白蒺藜的最大耐受倍数均大于loo，表明两药毒性甚 结论：削何首乌和白蒺藜对小鼠无急性毒性作用，两药按临床常用荆量单用或伍用时亦无急性肝脏毒性。 关键词 制何首乌；白蒺藜；毒性作用 on EffectsofRadix Multiflori andFructus ExperimentalStudyToxicity Polygoni Praeparata TribuliOllMice XIA ofChina Lei’，WANGLi-xia，MUJi—zheng(Dept．ofPharmacy，Guang’anmenHospital ofChineseMedical 100053，China) Academy Sciences，Beijing ABSTRACT0BJECTIVE：7I．othetoxiceffectsofRadix Muhiflori andFructusTribulion study Polygoni Praeparata mice．METHODS：Theacute ofRadix Muhiflori andFruetusTribuliwasevaluated toxicity Polygoni Praeparata by were medianlethaldoseandmaximaltolerancedose．The mice dividedintofour measuring experimental groups group，RadixMultiflori Tribuli Radix randomly：controlPolygoni Praeparatagroup，Fructusgroup，andPolygoni Muhiflori FructusTribuli wasobservedafter2一week Praeparataplus group。Thehepatotoxicity intragastric administrationofcommonclinicaldoseof Muhiflori andFructusTribulialoneorincombination． Polygoni Praeparata maximaltoleranceindexofRadix Multiflori andFmctusTribuliwereboth RESULTS：The Polygoni Praeparata greater than1 theirmild andTBAlevelsandtheliverindexhadno ALT，AST，ALP 00。suggestingtoxicit