DNA sensor in virus infection 脱氧核糖核酸识别受体与病毒感染.docVIP

DNA sensor in virus infection 脱氧核糖核酸识别受体与病毒感染.doc

  1. 1、本文档共19页,可阅读全部内容。
  2. 2、有哪些信誉好的足球投注网站(book118)网站文档一经付费(服务费),不意味着购买了该文档的版权,仅供个人/单位学习、研究之用,不得用于商业用途,未经授权,严禁复制、发行、汇编、翻译或者网络传播等,侵权必究。
  3. 3、本站所有内容均由合作方或网友上传,本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺!文档内容仅供研究参考,付费前请自行鉴别。如您付费,意味着您自己接受本站规则且自行承担风险,本站不退款、不进行额外附加服务;查看《如何避免下载的几个坑》。如果您已付费下载过本站文档,您可以点击 这里二次下载
  4. 4、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等,请点击“版权申诉”(推荐),也可以打举报电话:400-050-0827(电话支持时间:9:00-18:30)。
  5. 5、该文档为VIP文档,如果想要下载,成为VIP会员后,下载免费。
  6. 6、成为VIP后,下载本文档将扣除1次下载权益。下载后,不支持退款、换文档。如有疑问请联系我们
  7. 7、成为VIP后,您将拥有八大权益,权益包括:VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
  8. 8、VIP文档为合作方或网友上传,每下载1次, 网站将根据用户上传文档的质量评分、类型等,对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档
查看更多
DNA sensor in virus infection 脱氧核糖核酸识别受体与病毒感染.doc

DNA sensor in virus infection Abstract: In order to protect human from the detrimental effect of viral infection, immune system has evolved mechanisms to recognize and eradicate them. Recently, a novel antiviral tool of innate immune has been discovered桪NA osensors, which can recognize invading viral DNA and initiate innate antiviral responses, including the activation of type I interferons (IFNs) and proin?ammatory cytokines. These cytokines contributed to not only inhibiting viral replication in infected cells but also regulating the induction of adaptive immunity, leading to the swift eradication of viruses. All these indicate that DNA sensors play a pivotal role in antiviral response. Therefore, this article will provide an integral and comprehensive review of DNA sensor, focusing on sorts of DNA sensor, signaling pathway and the immune response triggered by them. What’s more, viral strategy against DNA sensors and negative regulation of host will be discussed as well. [Key words]: DNA sensor, virus infection, antiviral response, negative regulation of virus, negative regulation of host. 1. Introduction In order to protect host from infection of virus, innate immune has developed mechanisms of how to detect virus to trigger immune response. Recently, DNA sensor has been found as a novel tool to detect virus. Toll-like receptor (TLR) 9, retinoic acid-inducible gene I (RIG-I)-like receptors (RLRs) including RIG-I, melanoma differentiation-associated gene-5 (MDA5), DNA-dependent RNA polymerase III (Pol-III), DNA binding protein 1 (ZBP1) or DNA-dependent activator of IFN-regulatory factor (DAI), IFN-inducible p200-protein including p202,absent in melanoma 2 (AIM2),interferon-inducible protein 16 (IFI16) have been identified as DNA sensor[1-5]. What’s more, DExDc helicase DDX41, DHX36 and DHX9, Leucine-rich repeat flightless-interacting protein 1 (LRRFIP1), Ku70 were recently found to be novel DNA sensors [6-9]. Table 1 shows DNA sensors that have been discovered so

文档评论(0)

zhangchao11 + 关注
实名认证
文档贡献者

该用户很懒,什么也没介绍

1亿VIP精品文档

相关文档