B型金属β内酰胺酶抑制剂研究进展.pdfVIP

Chinese JournalofNew Drugs2011, 20(2) B 1, 2 1, 2 2 2 , , , ( 1 中国药科大学药物生物信息学教研室, 南京 210009; 2 中国药科大学微生物制药教研室, 南京 210009) [] B型金属 内酰胺酶( etallolacta ases,MBLs)抑制剂是目前在研的 有 内酰胺酶抑制 剂中较为热门的一类本文结合国内外文献以及课题组先前的工作, 简述了MBLs抑制剂的分类及其对 内酰胺酶(lacta ase)的抑制机制, 并列举了一些目前在研的化合物, 强调了开发MBLs抑制剂的紧迫性和 在临床应用中的现实意义随着研究的深入, MBLs抑制剂有望开发成为高效低毒的抑制剂, 在 一定程度 上解决临床上抗生素的细菌耐药问题, 从而使临床上相关抗生素的使用发生革命性的变化 [] 金属 内酰胺酶(MBLs)抑制剂;分类;抑制机制; 活性化合物; 临床意义 [] R97811 [] A [] 1003- 3734(2011)02- 0143- 05 Recent advance in the research of class B m etallolactamase inhibitors 1, 2 1, 2 2 2 SHEN B ingzheng , ZHENG Heng , NIMengxiang, GU Juefen ( 1D epartment of P harmaceutical B ioinf ormatics, China P harmaceutical University, Nanj ing 210009, China; 2D epartment of PharmaceuticalM icrobiology, China Pharmaceutical University, N anj ing 210009, Ch ina) [Abstract] The inhibitors of etallolacta ases (MBLs) were increasingly active in researches oflac ta ases inhibitorsWe presented the classification of etallolacta ase inhibitors and listed the inhibition ech anis , and a nu ber of the representation of co pounds in current researchTheurgency of the research and de velop entMBLs inhibitors and the practical significance in the clinical application were e phasizedFurther re searches and develop entsw illresult in effective and lowtoxicMBLs inhibitors, so that a revolutionary change can be expected in theuse of related antibiotics in clinicalapplication [K ey words] etallolacta ases (MBLs) inhibitor; classification; echanis of inhibitor; bioactive co pound; clinicalsignificance , , 1940 ,