2013年国际中药上市后再评价大_省略_药学会临床药理学分会年会会议通知_f47.pdfVIP

38 18 Vol. 38 ，Issue 18 第 卷第 期 20 13 9 September ，20 13 年 月 Ｒeal-world study of effect on liver function of parenterally administered Shuxuetong with different doses WANG Zhi-fei1 ，HUO Jian2 ，JIANG Jun-jie1 ，XIE Yan-ming1* (1. Institute of Basic Ｒesearch in Clinical Medicine ，China Academy of Chinese Medical Sciences ，Beij ing 100700 ，China ; 2. Ｒenmin University of China ，Beij ing 100872 ，China) ［Abstract］ Objective :To analyze the effect on liver function of parenterally administered Shuxuetong Injection with different doses． Method :The study is based on hospital information system (HIS)data． We group the cases by dose :The observation group receive a dose ＞ 6 mL (recommended daily dose)，the matched group receive the recommended dose． Chi-square test ，logistic regres- sion ，logistic regression with propensity score ，logistic regression with GBM propensity score were used to find the between group differ- ences in ALT and AST after using parentyerally administered Shuxuetong injection． Ｒesult :All tests show that there were no significant differences between groups in AST or ALT after we control for confounding factors． Conclusion :Based on HIS data ，there was no evi- dence to associate the use of Shuxuetong over the recommended dose and effects on liver function． ［Key words］ parenterally administered Shuxuetong ;hospital information system ;overdose ;real-world study ;liver function doi :10． 4268 / cjcm ［ ］