【荐】1-s2.0-S0008621513004084-main【荐】.pdfVIP

Carbohydrate Research 386 (2014) 62–67 Contents lists available at ScienceDirect Carbohydrate Research journal homepage: www.else /locate/carres Note Structural elucidation of the capsular polysaccharide from Streptococcus pneumoniae serotype 47A by NMR spectroscopy Bent O. Petersen a,⇑, Ole Hindsgaul a, Berit Smestad Paulsen b, Antonio R. Redondo c, Ian C. Skovsted c a Carlsberg Laboratory, 10 Gamle Carlsberg Vej, 1799 Copenhagen V, Denmark b Farmasøytisk insitutt, Sem Selands vei 3, 0316 Oslo, Norway c Statens Serum Institut, 5 Artillerivej, DK-2300 Copenhagen S, Denmark a r t i c l e i n f o a b s t r a c t Article history: The structure of the serotype 47A (Danish nomenclature system) capsular polysaccharide from Strepto- Received 19 July 2013 coccus pneumoniae was elucidated by NMR spectroscopy. The following structure of the repeating hepta- Received in revised form 18 November 2013 saccharide was deduced: Accepted 20 November 2013 Available online 1 December 2013 C β-D-Glcp-(1,6) ↓ F →6)-β-D-Galf -(3,5-di-OAc)-(1→3)-β-D-Galp-(1→4)-α-D-Glcp NAc-(1→4)-α-D-Galp-(1→2)-ribitol-(5→OPO → Keywords: 3 A