循环肿瘤细胞的检测和其在乳腺癌患者中的临床应用.pdfVIP

2010 11 15 11 Ch inese C lin icalOncology, Nov. 2010, Vol. 15, No. 11 ! 1037! 1 215006 江苏苏州 苏州大学附属第 一医院肿瘤科 马德亮 综述, 陶 敏 审校 ( circu lating tum or cel,l CTC), CT C CTC, CTC ; ; : R737 : A : 100 - 0460( 2010) 11- 1037- 04 D etection of circu lating tum or cells and its clin ical relevance in breast cancer MA D eliang, TA O M in. D ep artm en t of Oncology, the F irstH osp ital Aff iliated to Soochow University, Su hou 215006, China Corresp onding author: TAO M in, E ma il: m tao@ m edm ail. com. cn A bstract C ircu lating tumor cells are though t to reflect tumor aggressiveness and metastases, whose detection causes somuch interesting of researchers in the world. But circulating tum or cells in peripheral blood are rarew hich can be detected on ly by using spe cifically m arkers. Th is review addresses the enrichment and detection steps and them arkers of circu lating tumor cellsused in the litera tu re, also including its use in breast cancer. K eyW ords C ircu lating tumor cells; Detection; B reast cancer ( CTC) system ) CTC EpCAM , , CTC EpCAM ( progressionfree surviva,l PFS) ( overall [ 12] survival, OS) CTC , , CD45 , , , CTC , CD45 [ 3] 1 CTC 12 检测技术 11 富集方法 121 111 ISET ( isolation by s ize of epithelial tum or cells)( , 8m )