哺乳动物DGAT基因和其生物学功能研究进展.pdfVIP

HEREDITAS (Beijing) 2007 10 , 29(10): 1167―1172 ISSN 0253-9772 综述 DOI: 10.1360/yc-007-1167 DGAT 王彦, 许恒勇, 朱庆 , 625014 : 二酰基甘油酰基转移酶(DGAT, EC0)是一种微粒体酶, 与脂肪代谢、脂类在组织中的沉积有很大关 系, 它的主要作用机制是使二酰甘油加上脂肪酸酰基形成三酰甘油。DGAT 在细胞甘油代谢中起根本性的作用, 并在高等真核生物甘油三酯代谢途径如肠脂肪吸收、脂蛋白集合、脂肪形成和泌乳中发挥着重要的功能, 提示 DGAT 不仅是调控甘油三酯与脂肪酸之间的关键因子, 而且可能在动物脂肪沉积中起着关键的调控作用。 : 二酰基甘油转移酶; 生物学功能; 多态性 Progress in the study on mammalian diacylgycerol acyltransgerase (DGAT) gene and its biological function WANG Yan, XU Heng-Yong, ZHU Qing Animal Science and Technological College , Sichuan Agricultural University, Ya ’an 625014, China Abstract: Diacylglycerol acyltransferase (DGAT; EC 0) is a microsomal enzyme that plays a central role in the metabolism of cellular glycerolipids. DGAT catalyzes the final step in triacylglycerol (TAG) biosynthesis by converting diacylgycerol (DAG) and fatty acyl-coenzyme A (CoA) into triacylglycero1. DGAT plays a fundamental role in the metabo- lism of cellular diacylglycerol and is important in higher eukaryotes for physiologic processes involving triacylglycerol metabolism such as intestinal fat absorption, lipoprotein assembly, adipose tissue formation, and lactation. Therefore, DGAT is not only an key factor for control triglycerides and fatty acids, but also may play a key modulatory role in animal fat deposition. Keywords: diacylglycerol acyltransferase (DGAT); biological function; polymorphism (TAG) , , (diacylglycerol, DAG) (triacylglycerol, TAG), DAG , , C , , DGAT