丹参多酚酸盐对急性心肌梗死PCI术后CD14%2b单核细胞活性氧和Toll样受体及影响.pdfVIP

2014年中华中医药学会急诊分会年会暨急诊医学培训班 丹参多酚酸盐对急性心肌梗死PCI术后CDl4+ 单核细胞活性氧和Toll样受体的影响 王喜福1叶明1颜东2王旭1曾玉杰1 摘要：目的观察丹参多酚酸盐对急性心肌梗死PCI术后外周血单核细胞脂质过氧化损伤、单 核细胞趋化因子一1及Toll样受体的影响，以进一步探讨丹参多酚在拮抗急性心肌梗死单核细胞氧化 例 。常规治疗组予以阿司匹林、氯吡格雷及阿托伐他汀等药物口服。而丹参多酚治疗组除上述治疗 外，予以丹参多酚注射液400mg静点，此后每日一次，持续7天。入院时及治疗7天末取静脉血6m1 分离单核细胞，通过流式细胞仪、ELISA等方法检测单核细胞活性氧ROS、血浆单核细胞趋化因子 胞过氧化损伤，降低急性心肌梗死PCI术后患者单核细胞引起的炎性损伤。 关键词：丹参多酚酮，急性心肌梗死PCI术后，CDl4+单核细胞，Toll样受体 TheeffectsofDanshen 011 DuofensuanyanCDl4+monocyteperoxidation and in withacute infarctionafter injury patients Toll—like—receptor4 myocardial PCI Wangxi—ful，YeMin91，Yan Xul，ZhuXiao．1in91+ don92，Wang of35 Medical affiliated University 1．Departmentunit，Capital BeijingAnzhenHospital，Beijing； tO of Affiliated 2．DepartmentCardiology,ShougangHospital PekingUniversity，Beijing Toobservetheeffectof Danshen on Abstract：Objective ZhusheyongDuofensuanyanperipheral bloodmononuclearcells chemoattractantand lipidperoxidationinjury,Monocyte protein-1 in withacute infarctionafter Toll—like—receptor4patients myocardial percutaneouscoronary 作者单位：1．首都医科大学附属北京安贞医院35病区；2．|b京大学首钢医院心内科 王喜福博士主治医师邮箱wxf0439@163．com ．．．．——387．．．．—— 2014年中华中医药学会急诊分会年会暨急诊医学培训班 its mechanism．MethodsWechoosed320 withST elavationacute explorepossible patients Segment infarctionfromFeb2011 to 12inAnzhen allthe received myocardial Aug．20 Hospital，andpatients intotwo interventiontreatment．Allthe were divided percutaneouscoronary patientsrandomly groups： treatment DanshenDuofentreatment conventional conventionalgroup n 155 and group n 165 ．The treatmentwasadministeredwith theDanshen calcium，and group Aspirin，Clopidogrel，Atorvastatin Duofentreatmentwas administeredwithDanshen onceaday groupintravenously Duofensuanyan400mg for7 besides calcium．Beforeadmissionand7 later,6ml days Aspirin，Clopidogrel，Atorvastatin days venousbloodwasobtainedfromallthe were levelof monocytesseparated．Themonocytes patients，and reactive chemoattractant Toll-like oxygenspecies ROS ，monocyte andELISA．Andblood of30 healthy re