复方丹参滴丸对高脂血症患者红细胞变形性及影响其机制的分析.pdfVIP

2014年中华中医药学会急诊分会年会暨急诊医学培训班 复方丹参滴丸对高脂血症患者红细胞变形性的影响 及其机制分析 王喜福1祖晓麟1王成钢1王旭1王硕2曾玉杰p 摘要：目的观察传统中医药复方丹参滴丸对高脂血症患者红细胞变形性的影响，并探讨可能 和联合给药组各50例。其中单纯给药组予以瑞舒伐他汀lOmg每晚一次口服，联合给药组除予以瑞 4周后取外周静脉抗凝 舒伐他汀10mg每晚一次口服外，予以复方丹参滴丸10粒，每日3次口服i 血，运用传统激光衍射法检测红细胞变形性，生物化学方法检测红细胞膜Na+-K+一ATP酶活性， 用TBA方法检测血浆脂质过氧化产物丙二醛含量的变化。另选取30例健康自愿者为对照组，取静 脉血进行上述指标检测。结果与单纯给药组比较，联合给药组患者红细胞变形性于给药后4周末显 酶活性呈现升高趋势 p 0．05 。结论复方丹参滴丸能有效地改善高脂血症患者红细胞变形性，增 降低有关。 关键词：复方丹参滴丸；高脂血症；红细胞变形性； in Theeffectof Danshen ondeformationindexofRBC compounddrippingpill with andits mechanism． patientshyperlipidemiapossible Xifu Wan91，Xu Zhul术 Wan91，XiaolinZul，ChenggangWan91，ShuoWan92，Xiaoling of35 Medical affiliatedAnzhen word，CapitalUniversity 1．Department Beijing Hospital，Beijing；2． of Affiliatedto DepartmentCardiology,ShougangHospital PekingUniversity，Beijing To of index observetheeffect Danshen ondeformation Abstraet：Objective compounddrippingpill ofRBCin with to its mechanism．MethodsWechoosed100 patientshyperlipidemia，andexplorepossible with fromJul2009to 11 from of inanzhen patientshyperlipidemia Aug．20 Out—patientCardiologyHospital． Allthe were dividedintotwo administration combined patientsrandomly groups：pure group n 50 and administration administrationwasadministeredwithRosuvastatinCalcium group n 50 ．Thepure group 作者单位：1．首都医科大学附属北京安贞医院35病区，北京；2．北京大学首钢医院心内科，北京 ．．．．——403．．．．—— 2014年中华中医药学会急诊分会年会暨急诊医学培训班 was with Danshen combinedadministrationadministered 10mg／night ，and group compound dripping Rosuvastatin weeks later,blood pill 30pill／d besidesCalcium 10mg／nigh0．4 lipids were indexof ofNa+-K十一ATP ofRBC MDAlevel RBC，activity enzymes membrane，andplasma measured．And of30 volunteersweredetermined．ResultsTheRBCDeformation blood healthy samples indexof are with administrationblood combinedadministration group，the groupimprovedcomparedpure aleincreased． MDAlevelaredecreasedandthe ofNa+_K+ATPofRBCmembrane activity enzymes Conclusion Danshen Call RBCDeformationindexof pill significantly Compounddripping improve tothe