GVAX肿瘤疫苗临床研究现状和进展.pdfVIP

2011 3 18 6 CHIN J CANCER PREV TREAT , March 2011, Vol. 18 No. 6 477 GVAX 1, 2, 3 1 冯慧晶 , 谭晓华 1. 北京军区总医院生物治疗中心, 北京100700 2. 山西医科大学, 山西 太原030001 3. 山西省肿瘤医院生物治疗科, 山西 太原030013 Clinical trials of GVAX tumor vaccines: A current status and progression FENG H ui-j ing 1, 2,3 , TA N X iao-hua1 1. Biotherap y Center , Military General H osp ital of Beij ing , Beij ing 100700, P . . China 2. Shanxi Medical Univ ersity , Taiyuan 030001, P. . China 3. Dep artment of Biotherap y , Shanxi T umor H osp ital, Taiyuan 030013, P . . China : 总结国内外近几年对于 GVAX [ ABSTRACT] OBJECTIVE: To revie the recent advances in 瘤苗的临床研究现状: 应用 PubM ed 数 studies of GVAX tumor vaccine. METHODS: The PubMed da- 据库检 系统, 以 GVAX 瘤苗和 肿瘤免疫治 tabase from Jan 1993 to May 2010 as f iltered by using the 疗 等为关键词, 检 1993-01- 2010-05 关于 search terms GVAX tumor vaccine, Tumor immunothera- GVAX 瘤苗的制备及治疗各种肿瘤的文献资 py.Data election:The all literatures about GVAX vaccine, 17 料选择:选择所有与GVAX 瘤苗有关的文献, as internalized. RESULTS: GVAX tumor vaccine as the effect 最后纳入 17 篇:GVAX 瘤苗作为单药治 of monotherapy is limited, but for some tumors, GVAX tumor 疗肿瘤的效果有限,但对于一些肿瘤,GVAX 瘤 vaccine can extend the time to progression and the overall sur- 苗可不同程度地延长疾病进展时间和总体生存 vival, improve patients quality of life. Combined ith other 期, 改善患者生活质量联合其他的治疗方法 treatments such as chemotherapy, radiation therapy, minimally 如化疗放疗微创治疗和其他的免疫治疗等可 invasive treatment and other immune therapy, GVAX vaccine 能是GVAX 瘤苗以后研究的方向: 不同 may be the direction of future research. CONCLUSION: 的 GVAX 瘤苗已在各类肿瘤开展了一系列相 GVAX tumor vaccines have been carried out a series of related 关临床试验研究, 并显示出较好的安全性和有 clinical trials in diffe