JAK_STAT3和MAPK_E_省略_癌细胞侵袭转移中的交互作用及意义_陈红芳.pdf

20 09 36 4 293 DOI: 10 .3 971/j.issn. 100 0 857 8.2 00 9. 04 .0 09 JAK/ STAT 3 MAPK/ ERK 陈红芳, 邓华瑜 Cross-talking between JAK/ STAT3 and MAPK/ ERK Signaling Transduction Pathways on In asion and Metastasis of The Human Breast Cancer Cells CH EN Hong fang, DENG Hua yu Dep artment of Pathop hysiology , Chongqing Medical University , Chongqing 4 00 016, China Corresp onding A uthor: DEN G ua-yu, E-mail: cqdenghy@yahoo. Abstract: Objecti e T o explore the effect of Janus kinase inhibitor AG4 90 on phosphorylation of STAT3 and ERK in t he human breast cancer cell MDA M B 23 1 and to study the cross talking betw een JAK/ STAT3 and ERK/ MAPK signal :2 008 03 26 ; : 20 08 07 31 transduction pathw ays and the roles of :4 000 16 重庆医科大学病理生理教研室 these two pathw ays on invasion and : 邓华瑜, E mail: cqdenghy@. cn metastasis of human breast cancer : 陈红芳( 19 82 ) , 女,硕士, 主要从事肿瘤病理 生理 研究 cells. Methods MDA MB 23 1 cells Rg3 [ 7] Zhang Q, Kang X, Zhao W . Antiangiogenic effect of low dose , DDPRg3 cyclophosphamide combined w ith ginsenoside Rg3 on Lew is lung carcinoma[ J] . Biochem Biophys Res Commun, 2006, 342 , ( 3) : 824 828. Rg3 [ 8] Kim HS, Lee EH , Ko SR, et al. Effects of ginsenosides Rg3 and MVD DDP , Rg3 Rh2 on the pr oliferation of prostate cancer cells [ J] . Arch Pharm Res, 2004, 27(4) :