PD_1抗体在肿瘤治疗中的应用_曹佳彬.pdf

· · 中国生物制品学杂志2014 年6 月第27 卷第6 期 Chin J Biologicals June 2014 ，Vol. 27 No. 6 856 ·综 述 · PD-1抗体在肿瘤治疗中的应用 曹佳彬 ，魏敬双 华北制药集团新药研究开发有限责任公司抗体药物研制国家重点实验室，河北石家庄050015 摘要：肿瘤通过刺激免疫系统的抑制受体改变原有免疫反应，进行免疫逃逸。通过阻断T细胞抑制受体，阻断肿瘤 的发生，为抗肿瘤免疫提供了潜在的治疗方法。PD-1（programmeddeath-1）是T细胞抑制受体，在T细胞功能性紊乱 时持续表达，其可作为停止信号在肿瘤中限制T细胞的效应功能。阻断PD-1信号可有效帮助衰竭T细胞，促进抗 肿瘤免疫应答。PD-1抗体在癌症治疗及免疫刺激中具有重要作用，本文就PD-1及其配体、PD-1／PD-Ls信号通路以 及PD-1抗体在肿瘤治疗中的应用作一综述。 关键词：PD-1；抗体；肿瘤；T 细胞；检验点 中图分类号：R73-36 + 2 文献标识码：A 文章编号：1004-5503 （2014）06-0856-05 DOI:10.13200/ki.cjb.000414 Application of PD-1 antibody in therapy of tumors CAO Jia-bin，WEI Jing-shuang NCPC New Drug Research and Development Co. Ltd. ，State Key Laboratory of Antibody Drug Development ， Shijiazhuang 050015 ，Hebei Province ，China Corresponding author ：WEIJing-shuang ，E-mail ：weijsh@ Abstract ：Tumors are closely related to immune system and they can escape immune surveillance by stimulating immune inhibitory receptors ，which can be blocked by the inhibitory receptors on the T cell. This provides a potential method for anti-tumor immune therapy. PD-1 is an inhibitory receptor with sustained expression in T cell dysfunction，of which the primary function is to limit the T cell effector as the stop signal. Blocking PD-1 signal is effective in helping exhausted T cells ，which plays an important role in promoting the anti-tumor immune response. This review summarizes PD-1 and its ligands ，PD-1／ PD-Ls signaling pathway as well as the application of PD-1 antibody in the therapy of tumors. Key words ：PD-1；Antibody ；Tumors ；T cells ；Checkpoint 肿瘤具有多种抑制免疫系统及其效应因子的