兰菌净对反复呼吸道感染患儿唾液分泌型免疫球蛋白A水平影响_方红.pdfVIP

2004 6 19 6 J App l Clin Pediatr, J une 2004, Vol . 19 No. 6 455 兰菌净对反复呼吸道感染患儿唾液分泌型 免疫球蛋白A 水平影响 方 红, 金红芳, 董永绥, 王宏伟 ( 华中科技大学同济医学院附属同济医院儿科, 湖北武汉430030) [ ] 观察兰菌 对呼吸道黏膜免疫的激活效应及对反复呼吸道感染( RRI) 预防效果 选 择门诊病例35 例, 根据年龄分为3 组: 1 岁4 例1~ 3 岁18 例 3 岁 13 例, 兰菌 预防呼吸道感染, 由家长 记录或门诊随访呼吸道感染发作次数病程收集用药前后患儿唾液标本经放免法( DAB- PEG 法) 检测分泌型 免疫球蛋白A( sIgA) 含量, 并计算sIgA 提高率 兰菌 明显提高患儿唾液sIgA 含量( P 0. 01) , 显著降 低呼吸道感染的发病次数, 缩短病程, 减轻病情用药前后唾液sIgA 提高率以 1岁组最高, 3 岁组居中, 1~ 3 岁组最低治疗过程中不良反应轻微 兰菌 可有效激活呼吸道黏膜免疫, 预防呼吸道感染 , 2004, 19( 6) :455- 457 [ ] 兰菌 ; 反复呼吸道感染; 免疫球蛋白A, 分泌型 [ ] R725. [ ] A [ ] 1003- 515X(2004) 0 - 0455- 03 Effects of Lantigen B on salivary secretory immunoglobulin A level of chil ren with recurrent respiratory infec- tion FA N G H ong , JIN H ong - f ang , D ON G Yong - s ui , WA N G H ong - w ei ( Department of Pediatrics, Tongji Hospital Affiliated to T ongji M edical College of Huazhong University of Science and Technolo- gy, Wuhan 430030, China) Abstract: Objective To study the activation of Lantigen B on the respiratory mucous immune response and the precaution of re- current respiratory infection in children. Metho s T hirty- five outpatients were selected and divided into 3 groups according to their ages : 1 year ( n = 4) ; 1- 3 years( n = 18) ; 3 years ( n= 13) . Lantigen Bw as used to prevent respiratory infection. During the procedure, the number, duration and severity of recurrence and adverse effects were evaluated based on the records of parents or clinical follow - up. Saliva samples w ere coll