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单侧迷路破坏后大鼠前庭神经内侧核区氨基酸含量的变化.pdf
Acta Physiologica Sinica , February 25, 2007, 59 (1): 71-78 71
Research Paper
Changes of amino acid concentrations in the rat medial vestibular nucleus
following unilateral labyrinthectomy
1 2 2 2 2,*
YU Hai-Ling , AN Ying ,JIANG Hai-Ying ,JIN Qing-Hua , JIN Yuan-Zhe
1Department of Pharmacology; 2Department of Physiology, Yanbian University College of Medicine, Key Laboratory of Organism
Functional Factors of the Changbai Mountain, Ministry of Education, Yanji 133000, China
Abstract: To understand the neurochemical mechanisms underlying the vestibular compensation, we determined the levels of amino
acids such as aspartate, glutamate, glutamine, glycine, taurine, alanine in the medial vestibular nucleus (MVN) following unilateral
labyrinthectomy (UL), by using in vivo brain microdialysis and high-performance liquid chromatography technique. Rats were pre-
treated by infusing 2% lidocaine 1.2 mL or 10 mg arsanilic acid into the tympanic cavity to obstruct uni-periphery vestibular organ, and
then the levels of amino acids were determined in MVN of normal control and ipsilateral or contralateral lesional (ipsi-/contra-lesional)
rats. In the control experiment, the levels of aspartate, glutamate, glutamine, glycine, taurine, and alanine were (6.15±0.59), (18.13±1.21),
(33.73±1.67), (9.26±0.65), (9.56±0.77) and (10.07±0.83) pmol/8 µL sample, respectively. The concentrations of aspartate and
glutamate decreased, while the concentration of taurine increased in the ipsi-lesional MVN of rats 10 min after infusing 2% lidocaine
into middle ear to obstruct uni-periphery vestibular organ. Whereas the concentration of glutamate increased, the concentrations of
glycine and alanine decreased in the contra-lesional MVN, accompanied by imbalances of glutamate, glycine and alanine in the bilateral
nuclei. In contrast, the levels of glutamate and ala
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