人参皂甙Rg3对实验性小鼠大肠肿瘤的预防作用.pdfVIP

中华肿瘤防治杂志 2006 年 1 月第 13 卷第 1 期 　　C H IN J CAN CER PR EV TR EA T ,J anuary 2006 ,Vol . 13 　No . 1 ·19 · 实验研究 人参皂甙 Rg3 对实验性小鼠大肠肿瘤的预防作用 1 2 2 丁小文 , 　郑树 , 　彭佳萍 1. 浙江省肿瘤医院乳腺外科 , 浙江 杭州 3 10022 2 . 浙江大学肿瘤研究所 , 浙江 杭州 3 10009 Prevention of gin seno side Rg3 on color ect al neopla sm s induce d by DMH in mice 1 2 2 D I N G X i aow en , 　Z H E N G S h u , 　P E N G J i ap i ng 1. D ep a rt ment of B reas t S u rg ery , Z hej i ang Cance r H osp i t al , H ang z hou 3 10022 , P. R . Chi na 2. Cance r I ns ti t ute , Z hej i ang Uni ve rs i ty , H ang z hou 3 10009 , P. R . Chi na 【摘要】　目的:研究人参皂甙 Rg3 对二甲肼 [ ABSTRACT] 　OBJECTIVE : To study the prevention of ginseno side ( ) DM H 诱导的小鼠大肠肿瘤的预防作用及机 Rg3 on colorectal neoplasms in mice induced by dimethylhydrazine 制 。方法 :以DMH 诱导小鼠大肠肿瘤 ,诱癌 (DMH) . METHODS :The colorectal neoplasms were induced with DM H 第 8 周起予以不同浓度 Rg3 ,观察 Rg3 对大肠 in mice and the different do se of ginsenoside Rg3 were administered , then 肿瘤的化学预防作用;免疫组化方法检测 Rg3 the prevention of Rg3 on colorectal neoplasms was examined. The ex 对小鼠肠肿瘤 MVD 的影响以及 Rg3 对 V EGF pression of V EGF protein and intra tumoral microvessel density (MVD) 蛋白的表达影响。结果 :相比于阳性对照组 , were measured with immunohistochemistry methods. RESULTS :Com 不同浓度 Rg3 能够减少小鼠大肠癌发生率 pared with the control group , different do se of Rg3 reduced incidence of 40 %～50 % , P 005 ;平均荷瘤数减少 50 %～ carcinoma in mice about 40 % - 50 %( P 005) , average tumor amount 60 % , P 005 ;腺癌百分率减少 30 %～40 % ,