DCEPT方案治疗复发或难治性多发性骨髓瘤疗效观察.pdfVIP

维普资讯 肿瘤防治研究2008年第 35卷第 3期 ·209 · DCEP—T方案治疗复发或难治性多发性 骨髓瘤疗效观察 袁振刚，傅卫军，陈玉宝，奚 昊，王东星，侯 健 DCEP-T：AnEffective，Tolerated，SalvageCombinationChemotherapyforRelapsedorRe- fractoryM ultipleMyeloma YUANZhen-gang，FUWei—jun，CHENYu-bao，XIHao，WANGDong-xing，HOUJian DepartmentofHematology，ChangzhengHospital，TheSecondMilitaryMedicalUniversity，Shanghai 2000(}3．Chinn Abstract：Objective ToinvestigatetheefficacyofDCEP-T regimenintreatmentofpatientswithre— lapsedorrefractorymultiplemyeloma(MM )．Methods Twenty-eightpatients(19maleand9female， medianageis49years)withrefractoryorrelapsedmyelomahadbeentreatedwithDCEP-T foratleast twocycles．Theregimenconsistedof4daysofintravenousdexamethasone(20~40)rng／d，cyclophospha— mide200mg／d，etoposide40rag／m2，cisplatin10rag／m2，anddailythalidomide(100~200)mg／dina4一 ] ] weekcycle．Results AftertwocyclesofDCEP-T，4patients(14．3 )achievedverygoodcompletere— sponse．and14patients(5()．oV00)hadapartialresponse．Sotheoverallresponseratewas64．3 ．Among the9patientswith extramedullaryevolvement，plasmacytomacompletelydisappearedin4 patients，and decreasedmarkedlyin2patients，theresponseratewas66．7 (6／9)．Themostcommonnonhematologic toxicitieswerenauseaandvomiting (32．1 )，followedbyconstipation (25．0 )．Conclusion DCEP-T isaneffective．tolerable，salvagecombinationchemotherapyforrelapsedorrefractoryMM ，aswellasin extramedullaryevolvement． 收稿 日期：2007—03—06；修回日期：2007—07—02 Keywords；Multiplemyeloma；Cispla— 作者单位：200(X)3上海，第二军医大学附属长征 医院血 tin；Thalidomide 液科 摘 要：目的 观察 DCEP-T方案挽 作者简介：袁振刚 (1971一)，男，博士，主治医师，主要从 事 多发性骨髓瘤的研究 救性治疗复发或难治性 多发性骨髓瘤 为5