TPFPF方案诱导化疗联合同期放化疗治疗局部晚期鼻咽癌的近期疗效分析.pdfVIP

安 徽 医 药 AnhuiMedicalandPharmaceuticalJournal2011Oct；15(10) ‘1291· ◇药物与临床 ◇ TPF、PF方案诱导化疗联合同期放化疗治疗 局部晚期鼻咽癌的近期疗效分析 马静静 ，张云波，赵美红，宋玉秀，赵玉华，杜静波 (山东省淄博市万杰肿瘤医院，山东 淄博 255213) 摘要：目的 比较TPF、PF方案诱导化疗联合同期放化疗治疗局部晚期鼻咽癌的近期疗效及毒副反应。方法 45例 Ⅱb一Ⅳb期 鼻咽癌患者随机分为TPF组 (治疗组)、PF组 (对照组)，两组均行2周期诱导化疗 ，诱导化疗结束后一周开始同期放疗 ，期间观 察毒副反应 ，同期放化疗结束后 12周评价近期疗效。结果 两组主要毒副反应均为血液学毒性及消化系统反应，治疗组cR 率为 85．7％、PR为 14．3％，有效率为 100％。对照组 CR率为54．2％、PR为41．7％，总有效率 95．9％，两组之间近期疗效有统 计学差别。结论 TPF方案诱导化疗联合同期放化疗治疗局部晚期鼻咽癌近期疗效优于PF方案诱导化疗联合同期放化疗。 关键词：鼻咽癌 ；化学疗法 ；放射疗法；多西他赛；顺铂；氟尿嘧啶 Short．term treatmenteffectcomparison 0fTPF．PF induction chemotherapy followedby chemoradiotherapy forlocaladvancednasopharyngealcarcinoma MAJing—jing，ZHANGYun-bo，ZHA0Mei—hong，etal (TheWanfieTumorHospitalofZiboinShandong，Zibo 255213，China) Abstract：Aim ToinvestigateTPF，PF inductionchemotherapyfollowedbycocurrentchemoradiotheapyforlocaladvancednasopharyn— gealcarcinoma．Methods Forty—sevenpatientswithdiseasestageⅡb-1VbweretreatedwitheitherTPFgrouporPFgroup．Twogroups weregiven2cyclesinductionchemotherapy，thentworgoupsacceptedeocurrentchemotherapyandthesideeffectsobserved，12weeksaf- terchemoradiotherapyevaluatedtheshort—tern]effectofcurestrategy．Results Themainsideeffectswerehematologictoxcityanddiges— rivesystem toxicityoftwogroups．CR．PR were85．7％and 14．3％respectivelyinTPFgroup．Theoverallresponseratewas100％ ．CR． PRwere54．2％ and41．7％ respectivelyinPFrgoup．Theoverallresponseratewas95．9％ ．Thereweresignificantdifferencesbetween thetwogroups．Conclusion TheTPFinductionchemotherapycombinedchemoradiotherapytreatmentoflocaladvancednasopharyngeal carcinomaismoreeffectivethanthePF inductionchemotherapycombinedchemoradiotherapyinshort—term effects． Keywords：nasopharyngealcarcinoma；chemotherapy；radiotherapy；docetaxel；cisplatin；5一FU 鼻咽癌患者就诊时大约60％一70％已为局部晚期，放