24例大颗粒淋巴细胞白血病患者免疫表型和临床特征分析.pdf

内科急危蘑症杂志2010年第16卷第3期 24例大颗粒淋巴细胞白血病患者免疫表型和 临床特征分析★ 华中科技大学同济医学院附属协和医院贺艳丽 杨晶1 杜雯郑金娥刘伟 黄士昂。，武汉430022 摘要 目的：探讨大颗粒淋巴细胞白血病(LGLL)患者免疫表型与临床特征的关系。方法：收集24例I￡LL T-LGLL惰性与侵袭性患者组间比较，平均年龄、WBC计数、淋巴细胞比例、血红蛋白含量和B症状差异有显著意 有助于判断其侵袭性或惰性。 关键词T／NK一大颗粒淋巴细胞白血病免疫表型侵袭性 中图分类号R733．7 文献标识码A and Featuresof24CasesWith Granular LeukemiaHE ailⅡcaJ Large Yanli，YANG Immunophenotypes Lymphocyte Wen，eta1．Union to Medical Science Jing，DU HospitalAffiliatedTongji College，HuazhongUniversityof and 430(122，China Technology，Wuhan Abstract thecorrelationbetween andcliniealfeaturesin Objective：Toinvestigate immunophenotype patients with andclinicaldataof24 largegranular leukemia(LGLL)．Methods：Immunophenotypicprofile pa— lymphocyte between were anti— tientswithLGLLwerecollected，anddifferencesT／NK subtype andmost were inT-LGLL，butCD8+CD4一wasthe T-LGLL gen pan-Tantigenexpressed subtype．Aggressive showedlossofoneor andthe ofimmunofluorescenceinT anti— more change intensityantigen．Par卜T pan-Tantigens in CD3 CD2，CD7andNKassociatedCI)56and／orCDllcwereoften NK—IGLL，butwithnO gen antigen expressed andCD5 the noremarkabledifferenceinNK—LGLLindolentand expression．andimmunop