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EChapter.pdf
3. REPAIRING THE NERVOUS SYSTEM
WITH STEM CELLS
by David M. Panchision*
iseases of the nervous system, including focused on limiting damage once it had occurred, in
Dcongenital disorders, cancers, and degenerative recent years researchers have been working hard to
diseases, affect millions of people of all ages. find out if the cells that can give rise to new neurons
Congenital disorders occur when the brain or spinal can be coaxed to restore brain function. New neurons
cord does not form correctly during development. in the adult brain arise from slowly-dividing cells that
Cancers of the nervous system result from the appear to be the remnants of stem cells that existed
uncontrolled spread of aberrant cells. Degenerative during fetal brain development. Since some of these
diseases occur when the nervous system loses adult cells still retain the ability to generate both
functioning of nerve cells. Most of the advances in stem neurons and glia, they are referred to as adult neural
cell research have been directed at treating stem cells.
degenerative diseases. While many treatments aim to
limit the damage of these diseases, in some cases These findings are exciting because they suggest that
scientists believe that damage can be reversed by the brain may contain a built-in mechanism to repair
replacing lost cells with new ones derived from cells itself. Unfortunately, these new neurons are only
that can mature into nerve cells, called neural stem generated in a few sites in the brain and turn into only
cel
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