HurwitzPublicHealthServiceStudyofReyesSyndromeandMdedications.pdf

Public Health Service Study of Reyes Syndrome and Medications Report of the Main Study Eugene S. Hurwitz, MD; Michael J. Barrett, MD; Dennis Bregman, MS; Walter J. Gunn, PhD; Paul Pinsky, MPH; Lawrence B. Schonberger, MD; Joseph S. Drage, MD; Richard A. Kaslow, MD; D. Bruce Burlington, MD; Gerald V. Quinnan, MD; John R. LaMontagne, PhD; William R. Fairweather, PhD; Delbert Dayton, MD; Walter R. Dowdle, Ph Between January 1985 and May 1986, following completion of a pilot study, a public health questions, determine the main study concerning the possible association between Reyes syndrome and reliability of the pilot study findings, salicylates was conducted. Twenty-seven patients with stage II or deeper Reyes and expand the number and geographic distribution of cases and controls. syndrome whose diagnoses were confirmed by an expert panel and who had Data collection for the main study appropriate antecedent illnesses (chickenpox, respiratory illness, or gastroin- was conducted between January 1985 testinal illness) prior to the onset of Reyes syndrome were compared with 140 and May 1986 and involved the par¬ controls matched for age, race (black or not black), and type and timing of onset ticipation of 50 pédiatrie tertiary-care of antecedent illness. Controls were selected from the same hospital, emer- centers throughout the United States gency room, or school as case-patients or were identified by random-digit during the first 11 months. Twenty addi¬ telephone dialing. As in the pilot study, a strong statistical association with tional