rhGM-CSFIL-3融合蛋白对小鼠造血功能的影响.pdf

2000 盂。盅钟秀眦热。盏0嘣差圈T报Y De“17(6) ．。。，． rhGM—CSF／IL一3融合蛋白对小鼠造血功能的影响 王坤戴盛明1 肖桂元2周少雄2 (广西中医学院 南宁530001) 髓损伤和促进造血干／祖细胞增殖和分化的作用。 关键词rhGM—CSF／IL·3；RBC；ⅣBc；CFU—SI骨髓抑制 中国圈书资料分类法分类号R967 IN THEEFFECTOFrhGM—CSF／IL-3oNHEMOPO玎璐ISMICE Kun．Dai Guiyuan，et TraditionalChineseMedical Wang Shengming，Xaioa1．(Guangxi 530001。China) theeffectof on in model Abstract rhGM—CSF／IL一3hemopoiesismice．Methods：A Objective：Toinvestigate modelbonemanow in 60 ofbonemarrow a of radiation bycyclophosphamide(CTX)and juryby suppression was administeredtothemicefor Coirradiationwereestabfished．rhGM—CSF／IL一3 days intraperitoneaUy in bone of and themodelof real-row WBC，RBC，platletspleenweight suppression (1．25Fg／day)．Thechanges weredetectedCTXand unit(CFU—S)andsurvivalratesinthe by countingendogenousspleencolonyforming bone in WBC，RBCand manownucleolate modelofbonemarrowradiation platlet jury．Results：Theperipheral of w日e thanthose cellof at5 and10 afterCTXtreatmentsignificantly experimental day day