乙肝清热解毒胶囊联合拉米夫定治疗活动性肝炎肝硬化疗效分析.pdf

● ● 2009 1 1 16 论著 （ ， 061001 ） 观察乙肝清热解毒胶囊联合拉米夫定对活动性肝炎肝硬化患者的疗效。选择168例 中医辨证为肝胆湿热型的活动性肝炎肝硬化患者，按1 ∶1比例随机分为两组，治疗组口服乙肝清热 解毒胶囊及拉米夫定，对照组单用拉米夫定，疗程18个月。 治疗组治疗后在肝功复常率、HBV DNA低于检测下限的比率、HBeAg低于检测下限的比率、YMDD变异率方面均优于对照组且差异具 P 有显著性， 0.05 。 乙肝清热解毒胶囊联合拉米夫定对活动性肝炎肝硬化疗效显著，且在抑制 YMDD变异方面有一定疗效。 活动性肝炎肝硬化；乙肝清热解毒胶囊；拉米夫定；变异 Analysis on effect of hepatitis B Qingrejiedu capsule and lamivudine in treatment of patients with active liver cirrhosis XU Jing, GE Feng-qin, HUANG Gui-qin, LI Cang-you, GENG Jian-hong(Cangzhou Municipal Infectious Diseases Hospital, Cangzhou 061001,China) Abstract: Objective To observe the treatment effect of patients with active liver cirrhosis by the joint effort of hepatitis B Qingrejiedu capsule and lamivudine. Methods One hundred and sixty eight patients with active hepatitis liver cirrhosis belonged to liver and gallbladder damp heat type which is diagnosed by Chinese traditional medicine were selected, they were randomly divided into two groups according to the ratio of 1:1. The patients in the treatment group take oral hepatitis B Qingrejiedu capsules and lamivudine, while patients in the control group only take lamivudine, both treated for 18 months. Results After the treatment, normalization rate in liver function, HBV DNA negative conversion rate, HBeAg negative conversion rate and YMDD mutation rate were compared between the two groups, which were all superior in the treatment group than that in the control group, and the differences were significant, P 0.05. Conclusions The joint effort of hepatitis B Qingrejiedu cap