人参皂苷Rg3固体分散体的制备与体外特性研究.pdf

TraditionalandHerbal ·48· 中草菊 Chinese Drugs第39卷第1期2008年1月 人参皂苷R93固体分散体的制备与体外特性研究 孙考祥，吕会芳，梁容才，王爱萍，慕宏杰 (烟台大学药学院，山东，烟台264005) 接要：目的采用固体分散技术，比较3种不同载体对人参皂苷Rgs的溶解度和体外溶出度的作用。方法分别 Rg。固体分散体，测定溶解度，进行溶出度试验，并采用差热量热分析(DSC)法鉴别药物在固体分散体中的存在状 态。结果各种固体分散体均能显著增加人参皂苷Rgs的溶解度，加快其体外溶出。人参皂苷Rg。可充分分散在载 体中并形成低共熔物。结论F68作为载体制成固体分散体，对增加人参皂苷Rg。的溶解度和体外溶出度的效果 优于PEG和PVP。 关键词：人参皂苷Rg。；固体分散体；体外溶出度；溶解度 中图分类号：R286．1 文献标识码：A 文章编号：0253—2670(2008)01—0048—03 characteristicsof anddissolution solid of Preparation dispersion ginsenosideR93 SUN U Kao—xiang，L Hui—fang，LIANGRong—cai，WANGAi—ping，MUHong—jie (Schoolof Pharmacy，YantaiUniversity，Yantai264005，China) To thesolid of withdifferentcarriers Abstract：Objectiveprepare dispersion and ginsenosideR93 measuretheir and dissolutioncharacterisitics．MethodsThesolid of solubility dispersion ginsenosideR93 was the and with preparedby melteddissolvedmethodsPoloxamer188(F68)，PVPk29／32．andPEG6000 as anddissolutioncharacteristicsofthesolid i咒 carriers，respectively．Theequilibriumsolubility dispersion vitroweremeasuredHPLC．Thestateof inthesolid wasidentified by existing ginsenosideR93 dispersion thedifferential The was incarrier by scanningcalorimetery。ResultsginsenosideR93 completelydispe