大黄素soluplus聚合物胶束的制备及质量评价.pdf

第20卷第16期 中国实验方剂学杂志 V01．20，No．16 Chinese of TraditionalMedicalFormulae 2014年8月 Journal Aug．，2014 Experimental 大黄素soluplus聚合物胶束的制备及质量评价 典灵辉+，于恩江，程纪伦，郭向华，黄紫荣，张振声 (广东医学院药学院，广东东莞 523808) [摘要] 目的：制备大黄素的soluplus聚合物胶束并对其进行质量评价。方法：采用薄膜分散法制备大黄素聚合物胶束 醇m．1％磷酸(75：25)，检测波长437nm；采用动态膜透析法考察载药胶束的体外释药特性。结果：Emo—PMs呈球形或类球 程。结论：制备的Emo—PMs粒径、包封率、载药量可控，具有缓释作用。 [关键词】 大黄素；soluplus；聚合物胶束；质量评价；累积释放度；载药量；包封率 [中图分类号]R283．6；R284．1[文献标识码]A [文章编号]1005—9903(2014)16-0015-04 [doi]10．13422／j．cnki．syfjx．2014160015 11：05 【网络出版时间]2014-06—26 and EvaluationofEmodin-loaded PreparationQuality Micelles SoluplusPolymeric DIAN ji—lun，GUO Ling—hui+，yUEn-jiang，CHENGXiang—hua，HUANGZi—rong，ZHANGZhen—sheng Pharmaceutical Medical (School of Sciences，GuangdongCollege，Dongguan523808，China) emodin—loaded evaluate [Abstract]Objective：To prepare solupluspolymeric their were film method an quality．Method：Emo-PMspreparedby dispersion usingamphiphiliccopolymer werecharacterizedsize electron soluplus．Emo—PMs byparticleanalyzer，transmission curvewasdetermined membrane was to diffraction(XRD)；releasebydynamic dialysis；HPLCemployed determine and withmobile of entrapmentefficiency loading acid(75：25) drug phasemethanol-0．1％phosphoric anddetection ar437 showed withamean