类风湿关节炎患者疾病活动期和缓解期血清瘦素水平变化的意义.pdf

·1122· 类风湿关节炎患者疾病活动期和缓解期血清瘦素水平变化的意义 张凯1，廖丽翔2邓子辉1，薛辉1，郝秀华1，颜光涛1 1解放军总医院基础所生化室，北京100853；2浙江大学药学院，浙江杭州310058 B、IL-6、 检测96例类风湿性关节炎患者(活动期47例，缓解期49例)及40名健康对照者血清中瘦素、TNF—d、IL-I B、 B、IL-6、 可能作为一种协同炎性因子促进RA病情的进展。 关键词：瘦素；类风湿性关节炎；病情活动性 中图分类号：R392．11文献标识码：A 文章编号：1005-1139(2010)11-1122-03 their Serumlevelsin withactiveand rheumatoidarthritisand significance leptin patients non-activ．e ZHANG Xiu—hual，YAN Kail，LIAO Zi．huil，XUEHuil，HAO Guang—ta01 Li．xian92，DENG PLAGeneral of ofBasicMedicalInstitute，Chinese 1BiochemistryLaboratory Hospital，Beijing Pharmaceutical 310058，China Sciences，ZhejiangUniversity，Hangzhou author：YAN CorrespondingGuang—tao．Email：yan301@263．net rulesofserum levelsin withrheumatoid T0studvthe patients arthritisfRA)．MethodsActivit)r Abstract：Objectivechanging leptin ofRAwas tothe countdisease levelsof B，IL-6，RF, assayedaccording28-joint activityscore(DAS28)．Serumlepdn，肿a，Ⅱ，l 49 weremeasuredin40 controlsand96 47 withactiveRAand CRP,ESRandanti．CCP patients patients healthy includingpatients andanti—CCPWas The withnon．activeRA．CorrelationbetweenandTNF．0【，Ⅱ，l8，IL一6，RF,CRP,ESR