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乳状液膜包酶制备6-APA的研究.pdf
ChineseJ ofrhem
Eng,9(i)431—435(2001
RESEARCHNoTES
of6一APA Bioconversioninan
PreparationbyEnzymatic
EmulsionMembraneReactor+
Liquid
Lu andDENG
Qiang(陆强)8一,HuMing(胡鸣)8,XIONGDanliu(熊丹柳)6 XiuU5修)6
6UnilabResearchCenterofChemicalReaction China ofScienceand
Engineering、EastUniversity Technology,
200237,China
Shanghai
。Chemical E聃t
ResearchCenter China ofScienceand 200237China
Englneering University TechnologyShanghai
AbstractProductionof studied
6-aminopenicillanicacid(6-APA)byhydrolysispenicillinacylase(PA)was
using
越amode】ofall emulsion lossofPA examinedfor
enzymaticliquidlrlelnbrane(ELMlprocess.The activitywas
variousnlenlbrane solvent,surfactanteffectsofsolne variables
compositions(organiccarrier)The experimental
onthe ofemulsionwere Itwasfoundthatthechoiceof solvent affectedthe
stability investigated organic greatly
oftheemulsion the…㈣trationofthecarrier】nthemembraneincreasesthetransfer
Slability Iilcreasing phase
raLPofsubstratearid butalsohasadestabilizinzeffectOiltheemulsion.Theof6一APAobtained
products recovery
adi—carrier wasmuch thanthosewheneitherofthedi-carrierswasused
by systenlfN263·N19231 higher separately
was
Thewhole controlledboth the reactionrateand thetransferrateofthesubstrate
proce
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