乳痛宁巴布剂的制备及体外透皮释放研究.pdf

·制 剂 工 艺 Western Journal of Traditional Chinese Medicine,2015 Vol.28 No.3 乳痛宁巴布剂的制备及体外透皮释放研究 王长菊 1，付正英 2△ 1 天津中医药大学研究生学院，天津 300000； 2 天津市武警后勤学院附属医院 ［摘 要］目的：制备乳痛宁巴布剂,考察药物体外释放和透皮行为。 方法:以水溶性高分子材料为主要基 质，以光泽性、持粘力、基质残留和反复揭贴性等为指标，考察其对巴布剂物理性状的影响；采用立式 Franz 扩散池进行体外释放及透皮研究，运用紫外分光光度法测定柴胡皂苷 d 的含量。 结果:巴布剂基质最佳处方为 卡波姆∶聚丙烯酸钠∶羧甲基纤维素钠∶聚乙烯醇∶明胶∶甘油∶ 丙二醇 =0.4∶0.6∶0.6∶1.0∶1.8∶30∶30；中药：基质 =1∶ 4；柴胡皂苷 d 的累积透皮率为 20%，体外释放率为 49%。 结论:乳痛宁巴布剂的持粘力、光泽性、赋型性均较好， 制备工艺良好。 药物透皮行为符合零级动力学过程，体外释放符合 Higuchi 方程。 ［关键词］巴布剂；柴胡皂苷 d；透皮；释放；制备工艺；紫外分光光度法 ［中图分类号］R241 ［文献标识码］A ［文章编号］1004-6852(2015)03-0040-03 RuTongNing Cataplasma Preparation and Its Transdermal Study and Vitro Release 1 2△ WANG Changju , FU Zhengying 1 Tianjin University of Chinese Medicine, Tianjin 300000, China; 2 The Affiliated Hospital of Tianjing Institute of Logistics of Armed Police Objective: To prepare RuTongNing cataplasma and investigate its vitro release and transdermal be- havior. Methods: With the water-soluble polymer material as the main matrix and the indexes like the glossiness, holding power, residual matrix and repeated adhesive property as the inspecting indexes, the effects of the indexes on the physical properties of the cataplasma were investigated; the vitro release and transdermal study were per- formed in vertical Franz diffusion cell and the UV spectrophotometry was used to determine the content of saikos- aponin-d. Results: The optimum formula for cataplasma matrix was that carbomer/sodium polyacrylate/sodium car- boxymethylcellulose/polyving akohol/gelatin/glycerol/pr