Development of peptide and protein nanotherapeutics by nanoencapsulation and nanobioconjugation.pdf
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Development of peptide and protein nanotherapeutics by nanoencapsulation and nanobioconjugation
Peptides 32 (2011) 173–187
Contents lists available at ScienceDirect
Peptides
j o u rn al h omepage: w w w. elsev /locate/pept ides
Review
Development of peptide and protein nanotherapeutics by nanoencapsulation and
nanobioconjugation
Subhash Chandra Yadav ∗ , Avnesh Kumari, Ramdhan Yadav
Nanobiology Lab, Biotechnology Division, Institute of Himalayan Bioresource Technology, Council of Scientific and Industrial Research, Palampur 176061 HP India
a r t i c l e i n f o a b s t r a c t
Article history: The targeted delivery of therapeutic peptide by nanocarriers systems requires the knowledge of inter-
Received 15 September 2010 actions of nanomaterials with the biological environment, peptide release, and stability of therapeutic
Received in revised form 2 October 2010 peptides. Therapeutic application of nanoencapsulated peptides are increasing exponentially and 1000
Accepted 3 October 2010
peptides in nanoencapsulated form are in different clinical/trial phase. This review covers current sce-
Available online 8 October 2010
nario of therapeutic protein and peptides encapsulation on polymer to metallic nanocarriers including
methods of protein encapsulation, peptide bioconjugation on nanoparticles, stability enhancement of
Keywords:
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