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Development of peptide and protein nanotherapeutics by nanoencapsulation and nanobioconjugation.pdf

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Development of peptide and protein nanotherapeutics by nanoencapsulation and nanobioconjugation

Peptides 32 (2011) 173–187 Contents lists available at ScienceDirect Peptides j o u rn al h omepage: w w w. elsev /locate/pept ides Review Development of peptide and protein nanotherapeutics by nanoencapsulation and nanobioconjugation Subhash Chandra Yadav ∗ , Avnesh Kumari, Ramdhan Yadav Nanobiology Lab, Biotechnology Division, Institute of Himalayan Bioresource Technology, Council of Scientiﬁc and Industrial Research, Palampur 176061 HP India a r t i c l e i n f o a b s t r a c t Article history: The targeted delivery of therapeutic peptide by nanocarriers systems requires the knowledge of inter- Received 15 September 2010 actions of nanomaterials with the biological environment, peptide release, and stability of therapeutic Received in revised form 2 October 2010 peptides. Therapeutic application of nanoencapsulated peptides are increasing exponentially and 1000 Accepted 3 October 2010 peptides in nanoencapsulated form are in different clinical/trial phase. This review covers current sce- Available online 8 October 2010 nario of therapeutic protein and peptides encapsulation on polymer to metallic nanocarriers including methods of protein encapsulation, peptide bioconjugation on nanoparticles, stability enhancement of Keywords: