Intrahippocampal Infusions of KATP Channel Modulators Influence Spontaneous Alternation Pe.pdfVIP

The Journal of Neuroscience, January 15, 2001, 21(2):609–614 Intrahippocampal Infusions of K-ATP Channel Modulators Influence Spontaneous Alternation Performance: Relationships to Acetylcholine Release in the Hippocampus Mark R. Stefani1 and Paul E. Gold2 1Department of Psychiatry, Yale University School of Medicine, Veterans Affairs Medical Center, West Haven, Connecticut 06516, and 2Department of Psychology, University of Illinois at Urbana-Champaign, Champaign, Illinois 61820 One mechanism by which administration of glucose enhances tion scores relative to those of controls. Simultaneous admin- cognitive functions may be by modulating central ATP-sensitive istration of lemakalim with either glucose or glibenclamide re- potassium (K-ATP) channels. K-ATP channels appear to couple sulted in alternation scores not significantly different from glucose metabolism and neuronal excitability, with channel control values. All drug treatments enhanced hippocampal ACh blockade increasing the likelihood of neurosecretion. The output relative to control values. The results demonstrate that present experiment examined the effects of glucose and the K-ATP channel modulators influence behavior when adminis- direct K-ATP channel modulators glibenclamide and lemakalim tered directly into the hippocampus, with channel blockers on spontaneous alternation performance and hippocampal enhancing and openers impairing spontaneous alternation per- ACh release. Rats received either artificial CSF vehicle or vehi- formance, thus supporting the hypothesis that glucose en- cle plus drug for two consecutive 12 min periods via microdi- hances memory