条件恐惧大鼠消退保持与边缘下区磷酸化CREB的变化.pdfVIP

( J Fourth M ilM ed U n iv ) 2009, 30 ( 11) http: / /www. fmm uxb. cn 104 1 # # : 1000-2790( 2009) 11- 1041-04 CREB 1, 4 1 2 3 ( 1 , 7 10033, 2 刘俊丽 , 王正洪, 李 敏 , 饶志仁 , 4000 38, 3 , 7100 33, 4 , 8 1000 1) Change of extinction retention and sion of pCREB in 24 h ex tinction g roup w ere better than those in natural ex tinction and mi m ed ia te extinction g roup s [ ( 53 ? 12) , phosphorulated CREB in the rat infra-l ( 820 ? 106) , P 0. 01] and no sta tistica l d ifference w as found imbic cortex after conditioned fear betw een na tura l extinction group and mi med iate extinction group. 1, 4 1 2 3 Sham e A and B group s w e re low est scored ( 20 ? 7) and( 22 ? 6) LI U J un-L i , WAN G Zheng-H ong , LI M in , RA O Zh i-R en 1 D epartm ent of M ed ica l Educa tion R esearch, D iv ision of T ra ining, and the expression o f pCREB w as m ost depressed ( 4 32 ? 97) , Fourth M ilitary M ed ica l U niversity, X pian 710033, China, ( 453 ? 49) , w ith no sign if icant d ifference betw een group s. Com- 2 D epartm ent o f P sycho logy, Schoo l of N ursing, Th ird M ilitary pared w ith those in conditioned fear g roup, ex tinction re tention M ed ica lU niversity, Chongq ing 400038, Ch ina, 3 Institu te o f N eu- scores and the number expression of pCREB in IL show ed a g radual roscience, Fourth M ilitary M edica l U niversity, X pian 710033, uptrend on 1st, 3rd and 7 th day afte r ex tinction ( P 0. 0 1) . Ch ina, 4 Q ingha i H eal