一种新型载药超声微泡的制备.pdf

·666· ◆．◆实验研究 ofanovel ultrasoundmicrobubble Preparationdrug-loading WANG Hong-hon91’2，RANHai—ta01·2。，WANGZhi—gan91·2，ZHANG Ya—pin91’2．HAOLanl’2 (1．InstituteUltrasound Medical of Imaging，Chongqing 400010，China； University，Chongqing Second 2．DepartmentofUltrasound，theA}ftliatedHospital ofChongqing Medical 400010，China) University，Chongqing To the ofcovalent andstatic in ultrasoundmicro— [Abstract]Objectiveexploreefficiency bonding adsorptioncombining with bubblesactive tO anovel ultrasoundmicro— polylactie-co-glycolicacid(PLGA)nanospheres，andprepare drug-loading of bubble．MethodsPositive aminoultrasoundmicrobubbles(MB-NHz)werewithmechanical charge prepared shaking． PLGA doubleemulsificationmethod．PLGA Negativenanospheres(NP)werepreparedusing were method carbodiimidetOactivatethesurface ofNP．Thewasdividedintotwo to producedusing carboxyI study groups with combineultrasoundmicrobubblesPLGA collaborative nanospheres：Staticadsorptiongroup(MB-NH2+NP)and observed connectioneffectwas under atdifferenttime．ResultsAf— group(MB-