DNA甲基化与心力衰竭的相关性研究进展.pdf

·11742 · 中华临床医师杂志( 电子版)2013 年12 月第7 卷第24 期 Chin J Clinicians(Electronic Edition),December 15,2013,Vol.7,No.24 ·综述· DNA 甲基化与心力衰竭的相关性研究进展 吕鑫 赵翠萍 【摘要】 心力衰竭是心血管疾病的共同终末阶段，具有预后差、死亡率高等特点。DNA 甲基化与心 力衰竭存在着相关性，DNA 甲基化状态可以逆转为心力衰竭的治疗提供了一个契机。肌浆网Ca2＋-ATP 酶 参与心力衰竭的进程，通过改变肌浆网Ca2＋-ATP 酶的表达情况可以干预心力衰竭的进程。因此本文就DNA 甲基化与心力衰竭研究的关系进行论述，探讨其在心力衰竭发病及治疗方面的相关作用机制，并论述肌浆 网Ca2＋-ATP 酶在心力衰竭过程中所发挥的作用。 【关键词】 DNA 甲基化； 心力衰竭； 肌浆网钙转运ATP 酶类 The advances in DNA methylation correlated with heart failure LV Xin, ZHAO Cui-ping. Department of Cardiology, the First Affiliated Hospital of Harbin Medical University, Harbin 150001, China Corresponding author: ZHAO Cui-ping , Email: zhaocuiping2000@163.com 【Abstract 】 Heart failure is a common end-stage cardiovascular disease, with a poor prognosis and high mortality. There is a correlation between DNA methylation with heart failure, it is the DNA methylation can be reversed that provide an opportunity for the treatment of heart failure. Sarcoplasmic reticulum Ca2＋-ATP enzyme involves in the process of heart failure. By altering the expression of sarcoplasmic reticulum Ca2＋-ATP enzyme can interfere with heart failure process. Therefore, this paper is willing to discuss the relationship between DNA methylation and heart failure research, explore the related mechanisms in the pathogenesis and treatment of heart failure, and discusses the role of the sarcoplasmic reticulum Ca2＋-ATP enzyme in heart failure. 【Key words 】 DNA methylation; Heart failure; Sarcoplasmic reticulum calcium-transporting ATPases 心力衰竭（heart failure ）是心血管疾病的共同终末阶段， 不改变 DNA 碱基序列的基础上调控基因的表达。在哺乳动物 虽然近些年来对于心力衰竭的诊断及治疗均取得了较大的进 中，DNA 甲基化主要发生在CpG 二核苷酸上。而人类70% 的 [1]