《小剂量阿司匹林在动脉粥样硬化中的抗炎作用》.pdf

中国卒中杂志 2008年4月 第3卷 第4期 291 ・综述 ・ 小剂量阿司匹林在动脉粥样硬化中的 抗炎作用 王桂红，王拥军 【摘要】 小剂量阿司匹林通过抑制血小板内环氧化酶-1（COX-1）的活性，阻止血栓素A 的产生而 作者单位 2 发挥抗血栓作用，进而预防缺血性心脑血管疾病如心肌梗死及脑梗死的发生。研究提示，小剂量阿 100050 北京市 司匹林除了抗血小板活性外，还有其他的功能，如抗炎作用。本文重点探讨小剂量阿司匹林在动脉 首都医科大学附属北京 天坛医院神经内科 粥样硬化中的抗炎作用。 通信作者 【关键词】阿司匹林；动脉粥样硬化；环氧化酶；脂氧素类；一氧化氮 王拥军 yongjunwang111@ The Action of Anti-inflammation of Low-dose Aspirin in Atherosclerotic Disease WANG Gui-Hong, WANG Yong-Jun. Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing100050, China 【 】 Abstract Low-dose aspirin aspirin exerts anti-thrombotic action by acetylating and inactivating cyclooxygenase-1, preventing the production of thromboxane A in platelets, therefore low- 2 dose aspirin is considered as a preventative of ischemic diseases such as myocardial and cerebral infarction. However, many studies have revealed that aspirin has other beneficial actions in addition to its antiplatelet activity. In this review, we discuss the involvement of inflammation in atherosclerosis and how Low-dose aspirin aspirin exerts its anti-inflammation action in atherosclerotic diseases. 【 】 Aspirin; Atherosclerosis; Cyclooxygenase; L