农残分析质量控制（英文原版）.pdf

QUALITY CONTROL PROCEDURES FOR PESTICIDE RESIDUES ANALYSIS Document N° SANCO/10232/2006 24/March/2006 Table of contents Introduction 3 Accreditation 3 Sampling, transport, processing and storage of samples3 Pesticide standards, calibration solutions, etc. 4 Preparation, use and storage of working standards 5 Extraction and concentration 6 Extract concentration and dilution to volume 6 Contamination and interference 6 Contamination 7 Analytical calibration, representative analytes, matrix effects and chromatographic integration7 Calibration 8 Matrix effects and matrix-matched calibration 10 Standard Addition10 Effects of pesticide mixtures on calibration 10 Calibration for pesticides that are mixtures of isomers, etc. 11 Chromatographic integration 11 Analytical methods and analytical performance 11 Method validation11 Methods for determination of fat or dry weight content 12 Routine recovery determination 12 Proficiency testing and analysis of reference materials 13 Confirmation of results 14 Principles of confirmation 14 Confirmation by mass spectrometry (MS) 15 Confirmation by an independent laboratory17 Reporting of results 17 Expression of results17 Calculation of results 17 Rounding of data 17 Qualifying results with uncertainty data18 Interpretation of results19 Page 2 of 30 QUALITY CONTROL PROCEDURES FOR PESTICIDE RESIDUES ANALYSIS Introduction 1. The guidelines in this document are intended for the monitoring of pesticide residues in the European Union. The guidelines describe the analytical quality control (AQC) requirements to support the validity of data used for ch