111CRRT的评价.docVIP

第 PAGE 2 页 共 NUMPAGES 12 页 不同置换液流速的血液滤过对MODS患者预后影响的系统评价 解建 杨君 姜志明 摘要 目的 系统评价不同置换液流速的血液滤过对MODS患者预后的影响。方法 通过检索Medline、Embase、Cochrane临床试验数据库、CBM和CNKI等文献数据库, 全面收集全世界范围内不同置换液流速的血液滤过治疗MODS患者的随机对照试验（RCT），提取资料和评估方法学质量，而后采用Cochrane协作网RevMan5.0软件进行统计分析。结果 最终纳入9个RCT共276例MODS患者。Meta分析结果显示，HVHF组的死亡率为42.64%，CVVH组的死亡率为54.70%。两组间差异有统计学意义［OR=0.45，95%CI（0.25，0.79）, P=0.006］。结论 HVHF与CVVH治疗相比较，可以降低MODS患者的死亡率，改善MODS患者的预后。 关键词 血液滤过，多器官功能障碍综合征，系统评价, 随机对照试验 High volume hemofiltration versus continuous venovenous hemofiltration for multiple organ dysfunction syndrome: a meta-analysis. Xie Jian, Yang Jun, Jiang Zhi-ming（Department of Intensive Care Unit , Qianfoshan Hospital , Jinan , Shandong Province 250014 , China） 基金项目: 中文名称：山东省医药卫生科技发展计划（编号：2007HW115） 作者简介：第一作者: 解建（1956-），男(汉族) , 主任医师, 硕士导师, 山东省千佛山医院ICU ① 通讯作者: 解建, 山东省千佛山医院ICU. 山东 济南 250014. 联系电话 电子信箱：xiejian2509@ 【ABSTRACT】 Objective To systematically review the effects of high volume hemofiltration ( HVHF ) and continuous venovenous hemofiltration ( CVVH ) with multiple organ dysfunction syndrome ( MODS ). Methods We searched The Cochrane Library, PubMed, EMbase , CBM and CNKI. All randomized clinical trials of MODS requiring hemofiltration were included. Study selection and assessment, data collection and analyses were undertaken .Meta-analyses were done using The Cochrane Collaboration’s RevMan 5.0 software. Results Nine RCTs, involving a total of 276 MODS patients were included in the review. The mortality rate of HVHF group was 42.64%，and that of CVVH group was 54.70%. There was significant difference between them［OR=0.45，95%CI（0.25，0.79）, P=0.006］.Conclusion HYPERLINK /dict_result.aspx?searchword=%e6%af%94%e8%be%83tjType=sentencestyle=t=compared+with Compared with CVVH, HVHF has been shown to HYPERLINK /dict_result.aspx?searchword=%e9%99%8d%e4%bd%8e%e6%ad%bb%e4%ba%a1%e7%8e%87tjType=sentencestyle=t=reduce+the+mortality reduce the mortality of MODS and HYPERLINK /d