β-芳胺取代的型三唑类化合物的合成及生物活性的研究.pdf

13一芳胺取代的新型三唑类化合物的合成 及生物活性的研究 摘要 丙烯腈A，反应条件温和，后处理简便，产率较高，所有化合物均经元素分析 e§NHCH—C／CNN] A()(-H’llal。，。l吼幽湍粤 一 曲 曲 关键词：1“·1，2，4-三唑：丙烯腈；硼氢化钠；还嗫生物活性。 Studieson and Synthesis of Novel Bioactivity13．Aromatic Amine Sudstitutional 1,2，4-Triazole Compounds Abstracts Aseriesof substituted A d·(1H-1，2，4-triazol一1-y1)一13．arylamines acrylonitrile were in the synthesized reaction goodyieldby of withⅡ． nueleophilic arylamines out a (1H一1，2，4·triazol一1-y1)一8·dimethylamino-acrylonitrile hydroehloride．found mildand routine．Their structures were simple confirmedmeansofelemental by and E drawn 1HNMR,and were from analysis configurations thedataof1HNMR． Somewereverified IR by spectroscopy． X NHCH一／N3 A()(=H，halo，aU(yl，alkoxy，etc andselectiv