DNMT1 activates the canonical Wnt signaling in rheumatoid arthritis model rats via a crucial functional crosstalk between miR-152 and the DNMT1, MeCP2》.pdf

International Immunopharmacology 28 (2015) 344–353 Contents lists available at ScienceDirect International Immunopharmacology journal h omepage: /locate/intimp DNMT1 activates the canonical Wnt signaling in rheumatoid arthritis model rats via a crucial functional crosstalk between miR-152 and the DNMT1, MeCP2 Cheng-gui Miao a,b, Dan Qin a, Chuan-lai Du a, Hua Ye a, Wei-jing Shi a, You-yi Xiong a, Xiao-lin Zhang a, Hao Yu a, Jin-feng Dou a, Shi-tang Ma a, Mei-song Qin a, Han-zhen Liu a, Yan-xi Fang a, Guo-liang Zhou a, Jian-zhong Chen a, Xu He b, Cheng Huang b, Yan Huang b, Bing Zhang c, Tong-wen Song d, Jun Li b,⁎ a School of Food and Drug, Anhui Science and Technology University, Fengyang 233100, China b School of Pharmacy, Anhui Medical University, Hefei 230032, China c First Affi liated Hospital, Anhui Medical University, Hefei 230032, China d First Affi liated Hospital, Bengbu Medical College, Bengbu 233000, China a r t i c l e i n f o a b s t r a c t Article history: In previous study, we identified that microRNA (miR)-152 expression was down-regulated in RA model rats, and Received 30 March 2015 overexpression of miR-152 inhibited the canonical Wnt signaling through the DNA methyltransferase (DNMT1) Received in revised form 20 May 2015 inhibition. However, the exact molecular mechanisms of DNMT1 were unclear. In this work, we investigate Accepted 7 June 2015 whether DNMT1 affects the pathogenesis of RA model rats and targets the miR-152 promoter. The effects of Available online 18 June 2015