Dorsal root ganglion electrical stimulation promoted intertransverse process spinal fusion without decortications and bone grafting a proof-of-concept study》.pdf

The Spine Journal 14 (2014) 2472–2478 Basic Science Dorsal root ganglion electrical stimulation promoted intertransverse process spinal fusion without decortications and bone grafting: a proof-of-concept study a b a c Yuen-Chi Lau, MPhil , Yau-Ming Lai, PhD , Kai-Ting Po, BSc , Xing Qian, PhD , Hong-Wei Hao, PhDc c c a,* , Hu-Cheng Zhao, PhD , Lu-Ming Li, PhD , Xia Guo, MB, MD aDepartment of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hong Kong bDepartment of Health Technology and Informatics, The Hong Kong Polytechnic University, Hong Kong cSchool of Aerospace, Tsinghua University, China Received 12 February 2014; revised 25 March 2014; accepted 5 April 2014 Abstract BACKGROUND CONTEXT: Periosteum, endosteum, and bone are innervated by sensory nerves expressing calcitonin gene-related peptide (CGRP), which is a known osteoanabolic peptide and plays an important role in fracture healing and spinal fusion. Synthesis and release of CGRP are found in sensory neurons located in the dorsal root ganglions (DRGs) and can be upregulated by electrical stimulation (ES) at DRG. PURPOSE: To prove our study hypothesis on the potential of prec