Down-regulation of MSH2 expression by an Hsp90 inhibitor enhances pemetrexed-induced cytotoxicity in human non-small-cell lung cancer cells》.pdf

E X P E R I M E N T A L C E L L R E S E A R C H 3 2 2 ( 2 0 1 4 ) 3 4 5 – 3 5 4 Available online at journal homepage: /locate/yexcr Research Article Down-regulation of MSH2 expression by an Hsp90 inhibitor enhances pemetrexed-induced cytotoxicity in human non-small-cell lung cancer cells a, 1 b, 1 a,b b Chun-Liang Tung , Hsien-Chun Chiu , Yi-Jun Jian , Yun-Ting Jian , Chien-Yu Chenb b b b , Jhan-Jhang Syu , Ting-Yu Wo , Yi-Jhen Huang , Sheng-Chieh Tsengb, Yun-Wei Linb,n aDepartment of Pathology, Ditmanson Medical Foundation Chia-Yi Christian Hospital, Chiayi, Taiwan bMolecular Oncology Laboratory, Department of Biochemical Science and Technology, National Chiayi University, 300 Syuefu Road, Chiayi 600, Taiwan a r t i c l e i n f o r m a t i o n a b s t r a c t Article Chronology: Elevated heat shock protein 90 (Hsp90) expression has been linked to poor prognosis in patients Received 16 October 2013 with non-small cell lung cancer (NSCLC). The multitargeted antifolate pemetrexed has demon- Received in revised form strated certain clinical activities against NSCLC. However, the efficacy of the combination of 10 January 2014 pemtrexed and Hsp90 inhibitor to prolong the survival of patients with NSCLC still remains Accepted 4 February 2014 unclear. Human MutS homolog 2 (MSH2), a crucial element of the highly conserved DNA Available online 12 February