Dynamic changes in plasma tissue plasminogen activator, plasminogen activator inhibitor-1 and beta-thromboglobulin content in ischemic stroke》.pdf

Journal of Clinical Neuroscience 22 (2015) 1123–1127 Contents lists available at ScienceDirect Journal of Clinical Neuroscience journal homepage: /locate/jocn Clinical Study Dynamic changes in plasma tissue plasminogen activator, plasminogen activator inhibitor-1 and beta-thromboglobulin content in ischemic stroke Ping Zhuang b, Da Wo a, Zeng-guang Xu a, Wei Wei a, Hui-ming Mao a,⇑ a Department of Central Laboratory, Shanghai East Hospital, Tongji University, 150 Jimo Road, Pudong New District, Shanghai 200120, People’s Republic of China b Shanghai International Medical Center, Shanghai, People’s Republic of China a r t i c l e i n f o a b s t r a c t Article history: The aim of this paper is to investigate the corresponding variations of plasma tissue plasminogen activa- Received 31 March 2014 tor (t-PA) and plasminogen activator inhibitor-1 (PAI-1) activities, and beta–thromboglobulin (b-TG) Accepted 20 December 2014 content in patients during different stages of ischemic stroke. Ischemic stroke is a common disease among aging people and its occurrence is associated with abnormalities in the fibrinolytic system and platelet function. However, few reports focus on the dynamic changes in the plasma fibrinolytic system Keywords: and b-TG content in patients with ischemic stroke. Patients were divided into three groups: acute, Beta–thromboglobulin convalescent an