Early treatment response predicted subsequent clinical response in patients with schizophrenia taking paliperidone extended-release》.pdf

Psychiatry Research 230 (2015) 13–18 Contents lists available at ScienceDirect Psychiatry Research journal homepage: /locate/psychres Early treatment response predicted subsequent clinical response in patients with schizophrenia taking paliperidone extended-release En-Chi Yeh a,1, Ming-Chyi Huang a,b,1, Chang-Jer Tsai a,c, Chun-Tse Chen a, Kuan-Yu Chen a, Chih-Chiang Chiu a,b,n a Department of Psychiatry, Taipei City Psychiatric Center, Taipei City Hospital, Taipei, Taiwan b Department of Psychiatry, School of Medicine, Taipei Medical University, Taipei, Taiwan c Institute of Neuroscience, College of Science, National Chengchi University, Taipei, Taiwan a r t i c l e i n f o a b s t r a c t Article history: This 6-week open-labeled study investigated whether early treatment response in patients receiving Received 1 March 2015 paliperidone extended-release (paliperidone ER) can facilitate prediction of responses at Week 6. Pa- Received in revised form tients with schizophrenia or schizoaffective disorder were administered 9 mg/day of paliperidone ER 21 June 2015 during the first 2 weeks, after which the dose was adjusted clinically. They were assessed on Days 0, 4, 7, Accepted 12 July 2015 14, 28, and 42 by the Positive and Negative Syndrome Scale (PANSS). The serum concentrations of Available online 16 July 2015 9-hydroxyrisperidone were examined on Days 14 and