Effect of isolated unilateral diaphragmatic paralysis on ventilation and exercise performance in rats》.pdf

Respiratory Physiology Neurobiology 196 (2014) 25–32 Contents lists available at ScienceDirect Respiratory Physiology Neurobiology j o u r n a l h o m e p a g e : w w w. elsev /locate/res physiol Effect of isolated unilateral diaphragmatic paralysis on ventilation and exercise performance in rats Yali Xu a,b,c,d,e , Jing Rui a,b,c , Xin Zhao a,b,c , Chengwei Xiao a,b,c , Qiyuan Bao a,b,c , Jifeng Li a,b,c , Jie Lao a,b,c,∗ a Department of Hand Surgery, Huashan Hospital, Fudan University, Shanghai, People’s Republic of China b Key Laboratory of Hand Reconstruction, Ministry of Health, Shanghai, People’s Republic of China c Shanghai Key Laboratory of Peripheral Nerve and Microsurgery, Shanghai, People’s Republic of China d Department of Hand Surgery, The 3rd Hospital of Hebei Medical University, Shijiazhuang, Hebei Province, People’s Republic of China e Key Orthopaedic Biomechanics Laboratory of Hebei Province, People’s Republic of China a r t i c l e i n f o a b s t r a c t Article history: The degree of impairment of ventilation and exercise performance after unilateral diaphragmatic paral- Accepted 11 February 2014 ysis (UDP) induced by phrenic nerve injury has been controversial due to heterogeneity in the published clinical studies. The aim of this study was to assess the effect of isolated UDP on breathing and exercise Keywords: performance in conscious rats. Breathing was measured by unrestrained whole body plethysmography Unilateral diaphragmatic paralysis during quiet breathing and after moderate a