Effects of intracerebroventricular administered fluoxetine on cardio-ventilatory functions in rainbow trout (Oncorhynchus mykiss)》.pdf

General and Comparative Endocrinology 205 (2014) 176–184 Contents lists available at ScienceDirect General and Comparative Endocrinology journal homepage: www.else /locate/ygcen Effects of intracerebroventricular administered fluoxetine on cardio-ventilatory functions in rainbow trout (Oncorhynchus mykiss) Marc Kermorgant a, Frédéric Lancien a, Nagi Mimassi a, Charles R. Tyler b, Jean-Claude Le Mével a,⇑ a Université Européenne de Bretagne, Université de Brest, INSERM U1101, Laboratoire de Traitement de l’Information Médicale, Laboratoire de Neurophysiologie, SFR ScInBioS, Faculté de Médecine et des Sciences de la Santé, CHU de Brest, 22 Avenue Camille Desmoulins, CS 93837, 29238 Brest Cedex 3, France b Biosciences, University of Exeter, Exeter, United Kingdom a r t i c l e i n f o a b s t r a c t Article history: Fluoxetine (FLX) is a selective serotonin (5-HT) reuptake inhibitor present in the aquatic environment Available online 27 March 2014 which is known to bioconcentrate in the brains of exposed fish. FLX acts as a disruptor of various neuro- endocrine functions in the brain, but nothing is known about the possible consequence of FLX exposure Keywords: on the cardio-ventilatory system in fish. Here we undertook to investigate the central actions of FLX on Central fluoxetine ventilatory and cardiovascular function in unanesthetized rainbow trout (Oncorhynchus mykiss). Intracer- Intracerebroventricular injection ebroventricular (ICV) injection of FLX (dos