Efficacy and Safety of Dexamethasone Ointment on Recurrent Aphthous Ulceration》.pdf

CLINICAL RESEARCH STUDY Efficacy and Safety of Dexamethasone Ointment on Recurrent Aphthous Ulceration Chuanxia Liu, DDS, PhD,a Zengtong Zhou, DDS, PhD,b Guanjian Liu, PhD,c Qintao Wang, DDS, PhD,d Jiangang Chen, DDS, PhD,e Ling Wang, PhD,f Yongmei Zhou, MDS,b Guangying Dong, DDS, PhD,d Xueyi Xu, DS,g Yuechun Wang, MDS,e Yiqing Guo, MDS,a Mei Lin, MDS,a Lan Wu, DDS, PhD,b Gefei Du, DDS, PhD,g Changlei Wei, MDS,a Xin Zeng, DDS, PhD,a Xiaoyi Wang, DDS, PhD,a Junzheng Wu, DDS, PhD,d Bingqi Li, BDS,a Gang Zhou, DDS, PhD,g Hongmei Zhou, DDS, PhDa aState Key Laboratory of Oral Diseases, West China School of Stomatology, Sichuan University, Chengdu, China; bNinth People’s Hospital, School of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai, China; cChinese Evidence-Based Medicine Center, West China Hospital, Sichuan University, Chengdu, China; dCollege of Stomatology, the Fourth Military Medical University, Xi’an, China; eZhongnan Hospital, Wuhan University, Wuhan, China; f West China School of Pharmacy, Sichuan University, Chengdu, China; gSchool Hospital of Stomatology, Wuhan University, Wuhan, China. ABSTRACT OBJECTIVE: Recurrent aphthous ulceration is the most common oral mucosal lesion and may be associated with many systemic diseases. Topical corticosteroids are used frequently for recurrent aphthous ulceration; however, the number of high-quality clinical experiments available is insufficient, and no reports exist on the blood level of corticosteroids after topical usage in the oral mucosa. The objective was to determine the efficacy and safety of dexamethasone ointment in the treatment of recurrent aphthous ulceration and detect serum dexamethasone concentrations in the patients. MET