EGFR L858R mutation is associated with lung adenocarcinoma patients with dominant ground-glass opacity》.pdf

Lung Cancer 87 (2015) 272–277 Contents lists available at ScienceDirect Lung Cancer j o u rn al h omepage: w w w. elsev /locate/lung can EGFR L858R mutation is associated with lung adenocarcinoma patients with dominant ground-glass opacity Yong Yang a,1, Yang Yang a,1, Xiao Zhou a,1, Xiao Song a , Ming Liu a , Wenxin He a , Hao Wang a , Chunyan Wu b , Ke Fei c,∗∗ , Gening Jiang a,∗ a Department of Thoracic Surgery, Shanghai Pulmonary Hospital affiliated Tongji University, Shanghai 200433, China b Department of Pathology, Shanghai Pulmonary Hospital affiliated Tongji University, Shanghai 200433, China c Lung Cancer Diagnosis and Treatment Center, Shanghai Pulmonary Hospital affiliated Tongji University, Shanghai 200433, China a r t i c l e i n f o a b s t r a c t Article history: Objectives: To retrospectively identify quantitative computed tomographic (CT) features that correlate Received 17 October 2014 with the three major driver gene mutations in surgically resected lung adenocarcinomas with domi- Received in revised form nant ground-glass opacity (GGO) stratified by the International Association for the Study of Lung Cancer 30 November 2014 (IASLC), American Thoracic Society (ATS), and European Respiratory Society (ERS) classification in a Accepted 25 December 2014 Chinese cohort of patients. Materials and methods: Surgically resected lung adenocarcinomas from Shanghai