Epistasis of oxidative stress-related enzyme genes on modulating the risks in oral cavity cancer》.pdf

Clinica Chimica Acta 411 (2010) 1705–1710 Contents lists available at ScienceDirect Clinica Chimica Acta jour nal homepage: ww w. /locate/clinchim Epistasis of oxidative stress-related enzyme genes on modulating the risks in oral cavity cancer Szu-Hsien Wu a,b, Ka-Wo Lee c, Chien-Hung Chen d, Chun-Chin Lin e, Yang-Ming Tseng e, Hsu Ma a,b, Shih-Ming Tsai f,⁎, Li-Yu Tsai d,⁎ a Division of Plastic Surgery, Department of Surgery, Taipei Veterans General Hospital, Taipei, Taiwan b Department of Surgery, School of Medicine, Yang Ming University, Taipei, Taiwan c Department of Otolaryngology, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan d Department of Medical Laboratory Science and Biotechnology, College of Health Sciences, Kaohsiung Medical University, Kaohsiung, Taiwan e Department of Pathology and Laboratory Medicine, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan f Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan a r t i c l e i n f o a b s t r a c t Article history: Background: The aim of this study was to evaluate the risks of the polymorphisms of oxidant stress-related Received 16 March 2010 enzymes on patients with oral cavity cancer by genotyping of manganese superoxide dismutase (MnSOD Received in revised form 24 June 2010 [1183 TN C]), myeloperoxidase (MPO [–463G N A]), catalase (CAT [–15AN T]) and glutathione peroxidases 1 Accepted 9 July 2010 (GPx1 [Pro198Leu]). Available online 17 July 2010