ErbB-2 signaling plays a critical role in regulating androgen-sensitive and castration-resistant androgen receptor-positive prostate cancer cells》.pdf

Cellular Signalling 27 (2015) 2261–2271 Contents lists available at ScienceDirect Cellular Signalling journal homepage: /locate/cel lsi g ErbB-2 signaling plays a critical role in regulating androgen-sensitive and castration-resistant androgen receptor-positive prostate cancer cells Sakthivel Muniyan a, Siu-Ju Chen a, Fen-Fen Lin a, Zhengzhong Wang a, Parmender P. Mehta a, Surinder K. Batra a,b,c, Ming-Fong Lin a,b,d,e,⁎ a Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE, USA b Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE, USA c Department of Pathology, University of Nebraska Medical Center, Omaha, NE, USA d Department of Surgery/Urology, University of Nebraska Medical Center, Omaha, NE, USA e College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan, ROC a r t i c l e i n f o a b s t r a c t Article history: While androgen deprivation therapy (ADT) reduces tumor burden, autocrine growth factor loops such as human Received 22 May 2015 epidermal growth factor receptor 2 (HER2/ErbB-2/neu) have been proposed to contribute to prostate cancer Received in revised form 30 July 2015 (PCa) survival and relapse. However, the role of ErbB-2 in regulating androgen-sensitive (AS) and castration- Accepted 5 August 2015 resistant (CR) cell proliferation remains unclear. Here, we determined the role of ErbB-2 in PCa progression Available online 6 August 2015