Fabricating bio-inspired micronano-particles by polydopamine coating and surface interactions with blood platelets》.pdf

Applied Surface Science 351 (2015) 236–242 Contents lists available at ScienceDirect Applied Surface Science j o u rn al h o m e p a g e : w w w. elsev /locate/aps usc Fabricating bio-inspired micro/nano-particles by polydopamine coating and surface interactions with blood platelets Wei Ye a,b , Qiang Shi b,∗ , Jianwen Hou b , Jian Gao b , Chunming Li b , Jing Jin b , Hengchong Shi b , Jinghua Yin b,∗ a Jiangsu Provincial Key Lab for Interventional Medical Devices, Huaiyin Institute of Technology, Huaian 223003, China b State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China a r t i c l e i n f o a b s t r a c t Article history: Although bio-inspired polydopamine (PDA) micro/nano-particles show great promise for biomedical Received 10 March 2015 applications, the knowledge on the interactions between micro/nano-particles and platelets is still lack- Received in revised form 15 May 2015 ing. Here, we fabricate PDA-coated micro/nano-particles and investigate the platelet–particle surface Accepted 18 May 2015 interactions. Our strategy takes the advantage of facile PDA coating on polystyrene (PS) microsphere to Available online 27 May 2015 fabricate particles with varied sizes and surface properties, and the chemical reactivity of PDA layers to immobilize fibrinogen and bovine serum albumin to manipulate platelet activation and adhesion. We Keywo