High level of reactive oxygen species impaired mesenchymal stem cell migration via overpolymerization of F-actin cytoskeleton in systemic lupus erythematosus》.pdf

Pathologie Biologie 62 (2014) 382–390 Available online at ScienceDirect Original article High level of reactive oxygen species impaired mesenchymal stem cell migration via overpolymerization of F-actin cytoskeleton in systemic lupus erythematosus ´ ´ ´ ` L’augmentation des derives reactifs de l’oxygene (DRO) inhibe la migration des cellules ´ ´ souches mesenchymateuses (CSM) par l’intermediaire d’une augmentation ´ de la polymerisation du cytosquelette chez les patients atteints de lupus ´ ´ ´ ´ erythemateux dissemine D. Shi a,1, X. Li a,1, H. Chen a, N. Che b, S. Zhou a, Z. Lu b, S. Shi c, L. Sun a,* a Department of Immunology and Rheumatology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, 321, Zhongshan Road, 210008 Nanjing, Jiangsu, PR China b Department of Immunology and Rheumatology, Drum Tower Clinical Medical College of Nanjing Medical University, 321, Zhongshan Road, 210008 Nanjing, Jiangsu, PR China c Centerfor Craniofacial Molecular Biology, University of Southern California School of Dentistry, 1975,Zonal Avenue, CA 90089-9031 KAM B-16, Los Angeles, USA A R T I C L E I N F O A B S T R A C T Article history: Some lines of evidence have demonstrated abnormalities of bone marrow mesenchymal stem cells (MSCs) Received 17 January 2014 in systemic lupus erythematosus (SLE) patients, characterized by defective